Veterinary Clinical Reference

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Evergreen, evidence-based hubs on the drugs, conditions, and species you manage — continuously updated and cited at every claim.

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107 evergreen hubsCited at every claimContinuously updatedFree for verified vets

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Dogs & CatsJul 12, 2026

Clomipramine (Clomicalm) for Dogs and Cats: Behavioral Dosing, Efficacy, and Safety

Clomipramine is a tricyclic antidepressant FDA-approved (Clomicalm) as an adjunct to behavior modification for canine separation anxiety, and used off-label for feline urine marking and canine/feline compulsive disorders. This hub covers species-specific dosing, the registration and compulsive-disorder RCTs, adverse effects, MAOI/serotonergic interactions, and where it sits versus fluoxetine, trazodone, and buspirone.

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