Dog Cushing's Disease: Symptoms, Early Signs, and When to See a Vet

If your dog seems constantly thirsty, has a bloated belly that wasn't there before, and is losing patches of fur — you might be looking at Cushing's disease. In 2026, veterinarians commonly see this hormonal condition misidentified as "just getting old," which delays treatment for months or even years. Cushing's disease is manageable once diagnosed, but it requires knowing what to look for.

What Is Cushing's Disease in Dogs?

Cushing's disease (hyperadrenocorticism) happens when the body produces too much cortisol — the "stress hormone." According to VCA Animal Hospitals, this is one of the most common hormonal disorders in dogs, and it typically affects middle-aged to older dogs. Most cases are caused by a small benign tumor on the pituitary gland (pituitary-dependent), and a smaller percentage are caused by a tumor on one of the adrenal glands.

Breeds that appear more susceptible include Poodles, Dachshunds, Boxers, Boston Terriers, and Yorkshire Terriers — though any dog can develop it.

Common Symptoms of Cushing's Disease

The "Classic Four" Signs

The Merck Veterinary Manual describes four signs that appear in nearly every affected dog:

• Excessive thirst and urination — your dog drinks far more water than usual and has accidents in the house
• Increased appetite — your dog acts ravenously hungry despite eating normally
• Pot-bellied abdomen — the belly swells and sags due to fat redistribution and weakened abdominal muscles
• Hair loss and poor coat — symmetrical thinning, especially on the trunk and back legs, with dull or brittle fur

Less Obvious Early Signs

• Lethargy — decreased energy and interest in walks or play
• Panting — especially at rest or overnight, even when it's not warm
• Thin skin — skin may bruise easily, feel papery, or develop dark pigmented spots
• Recurrent infections — skin infections, ear infections, and urinary tract infections that keep coming back
• Muscle weakness — difficulty jumping up, climbing stairs, or rising from rest
• Calcinosis cutis — calcium deposits under the skin that form firm white bumps (a more advanced sign)

Because these symptoms develop gradually, many owners mistake them for normal aging. If your dog is drinking and urinating excessively, Cushing's disease is one of the top conditions your vet will want to rule out.

When to Worry: Emergency Signs

Cushing's disease itself isn't typically a sudden emergency — but complications can be. See a vet urgently if your dog:

• Collapses or is unable to stand
• Has a seizure
• Develops severe weakness in all four limbs
• Shows sudden bloating or abdominal pain (may indicate a different emergency)
• Has a urinary tract infection that isn't responding to antibiotics

Untreated Cushing's disease suppresses the immune system, making your dog vulnerable to serious bacterial infections and increasing the risk of diabetes, blood clots, and high blood pressure.

What to Do at Home

There's no safe home treatment for Cushing's disease — but here's what you can do while awaiting your vet appointment:

• Track the symptoms. Note when the excessive thirst and urination started, how much your dog is drinking, and any behavior changes. A written log helps your vet enormously.
• Don't restrict water. Dogs with Cushing's need to drink. Don't limit water access.
• Watch for skin infections. If you notice redness, odor, or discharge from the skin or ears, mention it to your vet — secondary infections need treatment.
• Monitor the belly. If the abdomen seems to be getting larger very quickly, call your vet sooner.

How Voyage Can Help

The combination of thirst, weight changes, and coat problems can point to several different conditions — Cushing's, diabetes, kidney disease, or thyroid issues. Voyage AI Vet can help you assess which symptoms are most concerning for your dog and whether a same-day vet visit is warranted, or if you have a few days — starting at $4.99/month.

If your dog is showing signs of diabetes or unexplained lumps under the skin, those could be related conditions worth discussing with your vet at the same appointment.

Frequently Asked Questions

Q: Can Cushing's disease be cured in dogs? A: Cushing's disease is rarely cured but is very manageable with medication (trilostane or mitotane). Most dogs do well with treatment and have a good quality of life for years.

Q: How is Cushing's disease diagnosed? A: Diagnosis usually requires blood tests — specifically a low-dose dexamethasone suppression test (LDDST) or ACTH stimulation test — along with urine tests and sometimes an abdominal ultrasound.

Q: My dog drinks a lot but looks fine otherwise. Could it be Cushing's? A: Possibly, but excessive thirst also points to diabetes, kidney disease, or liver problems. A simple blood and urine panel at your vet will help differentiate. Don't wait — these conditions are all easier to treat when caught early.

Q: What breeds are most affected by Cushing's disease? A: Poodles, Dachshunds, Boxers, Boston Terriers, and Beagles are among the most commonly affected breeds, but any dog can develop it, especially after age 6.

Q: Is Cushing's disease painful for dogs? A: Not directly painful, but the chronic skin infections, muscle weakness, and fatigue can significantly reduce quality of life. Treated dogs typically feel much better within weeks of starting medication.

This article is for informational purposes only and is not a substitute for professional veterinary advice.