Veterinary Clinical Reference
Look up any drug or condition.
Evergreen, evidence-based hubs on the drugs, conditions, and species you manage — continuously updated and cited at every claim.
Ibuprofen and Human-NSAID Toxicosis in Dogs and Cats
Ibuprofen and other human NSAIDs are among the most common OTC poisonings in dogs and cats. This clinical hub gives the verbatim mg/kg dose bands, the toxicokinetics behind repeat-dose charcoal, and an ER management plan: decontamination, 48-72h fluid diuresis, and layered GI protection - with no antidote and cats twice as sensitive as dogs.
Read →Amitriptyline in Dogs and Cats: Extralabel Behavioral Pharmacology, Dosing, and Evidence
A DVM-facing clinical reference on extralabel amitriptyline in dogs and cats: TCA mechanism, canine and feline dosing, adverse effects, serotonin syndrome interactions, monitoring, and the mixed feline idiopathic cystitis evidence.
Read →Sertraline (Zoloft) in Dogs and Cats for Behavior
Sertraline is an off-label SSRI used as a maintenance adjunct to behavior modification for anxiety, aggression, and compulsive disorders in dogs and cats. This clinical hub covers extralabel dosing, 4-6 week onset, adverse effects, and the load-bearing serotonin-syndrome interaction with MAO inhibitors.
Read →Clomipramine (Clomicalm) for Dogs and Cats: Behavioral Dosing, Efficacy, and Safety
Clomipramine is a tricyclic antidepressant FDA-approved (Clomicalm) as an adjunct to behavior modification for canine separation anxiety, and used off-label for feline urine marking and canine/feline compulsive disorders. This hub covers species-specific dosing, the registration and compulsive-disorder RCTs, adverse effects, MAOI/serotonergic interactions, and where it sits versus fluoxetine, trazodone, and buspirone.
Read →Acetaminophen (Paracetamol) Toxicosis in Dogs & Cats: Antidotal Management
An evidence-based clinical reference for DVMs on acetaminophen (paracetamol) toxicosis in dogs and cats: why cats are exquisitely sensitive, species-split toxic doses, methemoglobinemia vs hepatotoxicity, and the N-acetylcysteine antidote protocol with adjuncts.
Read →Ethylene Glycol Toxicosis in Dogs and Cats: Clinical Management
A time-critical toxicology reference for clinicians: ethylene glycol toxicokinetics, species-specific lethal doses, the three clinical stages, early diagnosis (osmolar and anion gaps, calcium oxalate crystalluria), and the antidote race with fomepizole and ethanol dosing for dogs and cats.
Read →Tramadol in Dogs and Cats: An Atypical Analgesic With a Critical Species Divide
Tramadol's opioid activity depends on the M1 metabolite dogs barely produce, so oral monotherapy fails for canine osteoarthritis while cats fare better. A clinical review of the evidence, dosing, and interactions.
Read →Ondansetron in Dogs and Cats: A Clinical Reference for Vomiting and Nausea
A practicing-clinician reference on ondansetron for dogs and cats: mechanism, indications, oral and IV dosing, the low-oral-bioavailability problem, how it compares with maropitant and metoclopramide, adverse effects, and the efficacy evidence.
Read →Azathioprine in Dogs — and Why It Is Contraindicated in Cats
A clinical reference on azathioprine as a steroid-sparing immunosuppressant in dogs, the feline TPMT contraindication that makes it dangerous in cats, myelotoxicity and hepatotoxicity monitoring, drug interactions, and chlorambucil as the thiopurine-sparing alternative.
Read →Amoxicillin-Clavulanate (Clavamox) in Dogs and Cats: Indications, Stewardship, and Skin and UTI Evidence
Amoxicillin-clavulanate covers beta-lactamase-producing Staphylococcus and E. coli in skin/UTI. ISCAID 2019 prefers amoxicillin alone for uncomplicated ...
Read →Doxycycline for Tick-Borne Disease in Dogs and Cats: Ehrlichia, Anaplasma, RMSF, and Lyme
Doxycycline 10 mg/kg/day for 28 days treats all major tick-borne infections in dogs and cats; short courses risk recrudescence. Esophageal stricture ris...
Read →Prednisolone and Prednisone in Dogs and Cats: Pharmacology, Dosing, and Adverse Effect Management
Prednisolone is the preferred oral glucocorticoid in cats (~100% bioavailability vs ~21% for prednisone), while dogs treat the two as equivalent. A clinician-facing evidence summary of dosing, tapering, adverse effects, and steroid-sparing agents across dogs and cats.
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