Veterinary Clinical Reference
Look up any drug or condition.
Evergreen, evidence-based hubs on the drugs, conditions, and species you manage — continuously updated and cited at every claim.
Prednisolone and Prednisone in Dogs and Cats: Pharmacology, Dosing, and Adverse Effect Management
Prednisolone is the preferred oral glucocorticoid in cats (~100% bioavailability vs ~21% for prednisone), while dogs treat the two as equivalent. A clinician-facing evidence summary of dosing, tapering, adverse effects, and steroid-sparing agents across dogs and cats.
Read →Methimazole and Carbimazole for Feline Hyperthyroidism: Pharmacology, Dosing, and Adverse Effect Management
Methimazole 1.25-2.5 mg PO BID is the standard medical therapy for feline hyperthyroidism, controlling but not curing disease. This hub consolidates dosing, adverse-effect management, carbimazole and transdermal options, and how medical management compares with radioiodine, iodine-restricted diet, and surgery — including the concurrent-CKD reversibility trial.
Read →Velagliflozin (Senvelgo) for Feline Diabetes Mellitus: SGLT2 Inhibition, Efficacy and Safety
Velagliflozin (Senvelgo) is a once-daily oral SGLT2 inhibitor for the insulin-naive diabetic cat: the SENSATION trial (n=252) cut median blood glucose from 436 to 125 mg/dL by day 180. This hub covers efficacy, the euglycemic DKA hazard, mandatory BHB monitoring, patient selection, and how it compares with bexagliflozin and insulin.
Read →Robenacoxib for Feline Musculoskeletal Pain: COX-2 Selectivity, DJD Evidence, Safety, and the ISFM/AAFP Framework
The evergreen clinical hub on robenacoxib (Onsior) for feline musculoskeletal and DJD pain: COX-2 tissue selectivity and PK, the Adrian 2021 pilot RCT (49% disability reduction, NNT 3.8), King 2021 pooled chronic safety with a CKD subgroup, grapiprant comparator and NSAID-timing data, and the 2024 ISFM/AAFP monitoring framework.
Read →Pimobendan for Canine Myxomatous Mitral Valve Disease (MMVD): Evidence, Mechanism, and Use
Pimobendan's dual calcium-sensitizer and PDE3-inhibitor mechanism, the EPIC and QUEST pivotal trials, 2019 ACVIM staging, PROTECT DCM data, and the 2024-2026 reverse-remodeling evidence that says document baseline echo before you dose a Stage B2 dog.
Read →Sarolaner for Canine Generalized Demodicosis: Efficacy, Class Pharmacology, and Safety
Oral sarolaner-based isoxazolines clear Demodex canis in generalized demodicosis: a masked field study reached 100% mite reduction by Day 90.
Read →Cannabidiol (CBD) for Canine Idiopathic Epilepsy: What the Controlled Trials Show
Two randomized trials and a pilot cohort show CBD added to antiseizure drugs modestly cuts seizure frequency in dogs, but not the 50%-responder rate; ALP rises consistently, so monitor the liver and watch CYP450 interactions.
Read →Zonisamide for Canine Idiopathic Epilepsy: Efficacy, Tolerability, and Therapeutic Drug Monitoring
Evidence review for veterinarians: a 207-dog TDM cohort proposes a 10-55 mcg/mL canine reference interval and 76% of newly-diagnosed dogs reached >=50% seizure reduction on monotherapy, with feline tolerability signals from a 57-cat cohort.
Read →Levetiracetam for Canine Idiopathic Epilepsy: Comparative Outcomes, Serum Monitoring, and Intranasal Emergency Use
Evidence review of levetiracetam for canine idiopathic epilepsy: outcomes similar to zonisamide and phenobarbital with fewer adverse effects, the phenobarbital serum interaction, intranasal emergency PK, and the class-level weight-gain effect. Includes rTMS and metabolic adjuncts for drug-resistant cases.
Read →Omeprazole and Gastroprotectants in Dogs: ACVIM Consensus, Overprescription Evidence, and Drug Interactions
Evidence-based review for DVMs: the 2018 ACVIM consensus reshaped omeprazole prescribing, yet a 265-vet survey shows persistent overprescription; long-term use raises gastrin without cobalamin change, and the feline clopidogrel interaction is PK-real but PD-limited.
Read →Enflicoxib (Daxocox) for Canine Osteoarthritis: A Once-Weekly COX-2 Selective NSAID
Enflicoxib (Daxocox) is an EU-authorised, once-weekly COX-2 selective NSAID for canine osteoarthritis. This hub reviews its mechanism, 6-month field efficacy and safety (Salichs 2024), long-term durability, comparators, and clinical placement.
Read →Lokivetmab (Cytopoint) for Canine Atopic Dermatitis: IL-31 Targeting and Clinical Evidence
Lokivetmab (Cytopoint) neutralizes IL-31 to control pruritus in canine atopic dermatitis. Evergreen review of pivotal RCTs, 12-month durability, ciclosporin comparison, COLT combination therapy, and the 2024-2025 JAK-inhibitor landscape.
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