Veterinary Clinical Reference
Look up any drug or condition.
Evergreen, evidence-based hubs on the drugs, conditions, and species you manage — continuously updated and cited at every claim.
Robenacoxib for Feline Musculoskeletal Pain: COX-2 Selectivity, DJD Evidence, Safety, and the ISFM/AAFP Framework
The evergreen clinical hub on robenacoxib (Onsior) for feline musculoskeletal and DJD pain: COX-2 tissue selectivity and PK, the Adrian 2021 pilot RCT (49% disability reduction, NNT 3.8), King 2021 pooled chronic safety with a CKD subgroup, grapiprant comparator and NSAID-timing data, and the 2024 ISFM/AAFP monitoring framework.
Read →Pimobendan for Canine Myxomatous Mitral Valve Disease (MMVD): Evidence, Mechanism, and Use
Pimobendan's dual calcium-sensitizer and PDE3-inhibitor mechanism, the EPIC and QUEST pivotal trials, 2019 ACVIM staging, PROTECT DCM data, and the 2024-2026 reverse-remodeling evidence that says document baseline echo before you dose a Stage B2 dog.
Read →Sarolaner for Canine Generalized Demodicosis: Efficacy, Class Pharmacology, and Safety
Oral sarolaner-based isoxazolines clear Demodex canis in generalized demodicosis: a masked field study reached 100% mite reduction by Day 90.
Read →Cannabidiol (CBD) for Canine Idiopathic Epilepsy: What the Controlled Trials Show
Two randomized trials and a pilot cohort show CBD added to antiseizure drugs modestly cuts seizure frequency in dogs, but not the 50%-responder rate; ALP rises consistently, so monitor the liver and watch CYP450 interactions.
Read →Zonisamide for Canine Idiopathic Epilepsy: Efficacy, Tolerability, and Therapeutic Drug Monitoring
Evidence review for veterinarians: a 207-dog TDM cohort proposes a 10-55 mcg/mL canine reference interval and 76% of newly-diagnosed dogs reached >=50% seizure reduction on monotherapy, with feline tolerability signals from a 57-cat cohort.
Read →Levetiracetam for Canine Idiopathic Epilepsy: Comparative Outcomes, Serum Monitoring, and Intranasal Emergency Use
Evidence review of levetiracetam for canine idiopathic epilepsy: outcomes similar to zonisamide and phenobarbital with fewer adverse effects, the phenobarbital serum interaction, intranasal emergency PK, and the class-level weight-gain effect. Includes rTMS and metabolic adjuncts for drug-resistant cases.
Read →Omeprazole and Gastroprotectants in Dogs: ACVIM Consensus, Overprescription Evidence, and Drug Interactions
Evidence-based review for DVMs: the 2018 ACVIM consensus reshaped omeprazole prescribing, yet a 265-vet survey shows persistent overprescription; long-term use raises gastrin without cobalamin change, and the feline clopidogrel interaction is PK-real but PD-limited.
Read →Enflicoxib (Daxocox) for Canine Osteoarthritis: A Once-Weekly COX-2 Selective NSAID
Enflicoxib (Daxocox) is an EU-authorised, once-weekly COX-2 selective NSAID for canine osteoarthritis. This hub reviews its mechanism, 6-month field efficacy and safety (Salichs 2024), long-term durability, comparators, and clinical placement.
Read →Lokivetmab (Cytopoint) for Canine Atopic Dermatitis: IL-31 Targeting and Clinical Evidence
Lokivetmab (Cytopoint) neutralizes IL-31 to control pruritus in canine atopic dermatitis. Evergreen review of pivotal RCTs, 12-month durability, ciclosporin comparison, COLT combination therapy, and the 2024-2025 JAK-inhibitor landscape.
Read →Robenacoxib (Onsior) for Pain in Cats and Dogs: COX-2 Selectivity and Clinical Evidence
Robenacoxib (Onsior) is a COX-2-selective NSAID with tissue-preferential distribution. Evidence from a feline DJD RCT and perioperative comparison data reviewed.
Read →Potassium Bromide (KBroVet) for Canine Idiopathic Epilepsy: FDA Full Approval, Dosing, and Monitoring
KBroVet (potassium bromide) received FDA full approval in January 2026 for canine idiopathic epilepsy. A clinical reference on mechanism, dosing, pharmacokinetics, bromism, and the real-world serum-monitoring gap (31.6% for bromide vs 77.5% for phenobarbital).
Read →Fluralaner (Bravecto) for Canine Generalized Demodicosis: Field Study Evidence
Two controlled studies confirm 98–100% mite-free rates with a single fluralaner administration for canine generalized demodicosis, outperforming imidacloprid/moxidectin — with 2026 data extending single-dose cure to sarcoptic mange and reviews refining the isoxazoline MDR1 neurologic-safety signal.
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